XEOMIN Injection 100U – Botulinum Neurotoxin Type A

XEOMIN 100U

Product Overview  

XEOMIN 100U is a purified botulinum toxin type A product (incobotulinumtoxinA) manufactured by Merz Pharmaceuticals GmbH (Germany),supplied as a white to off-white lyophilized powder. It is free from complexing proteins, which may reduce the risk of antibody formation and associated treatment resistance. XEOMIN is indicated for both therapeutic and aesthetic uses.

Key Features  

- Contains 100 Units of incobotulinumtoxinA per vial.  

- Lacks complexing (accessory) proteins, containing only the 150 kDa neurotoxin.  

- Manufactured with high purity and low endotoxin content.  

- Available worldwide with regulatory approvals including FDA and EMA.  

- Stability at room temperature before reconstitution allows easier handling.

Indications  

- Therapeutic: Blepharospasm, hemifacial spasm, cervical dystonia, focal spasticity of upper and lower limbs, chronic sialorrhea due to neurological disorders.  

- Aesthetic: Treatment of moderate to severe glabellar frown lines, lateral periorbital lines (crow’s feet), and horizontal forehead lines.

Composition  

- IncobotulinumtoxinA (100 U per vial).  

- Excipients include human albumin and sucrose.  

- No preservatives; free from hemagglutinins and non-toxic proteins.

Mechanism of Action  

- Inhibits acetylcholine release at the neuromuscular junction causing temporary muscle relaxation.  

- Reduces muscle contraction responsible for wrinkles and spasticity.

Preparation & Administration  

- Reconstituted with sterile, preservative-free 0.9% saline.  

- Intramuscular use with injection sites and doses tailored to clinical indication.  

- Should only be administered by trained healthcare professionals.

Storage  

- Store unopened vials refrigerated between 2°C and 8°C.  

- Protect from light and freezing.  

- Use reconstituted solution promptly as per manufacturer’s guidelines.

Results  

- Clinical effects typically begin within 3 to 7 days.  

- Peak effect around 2 weeks post-injection.  

- Duration typically lasts 3 to 4 months depending on indication and patient factors.  

- Repeat treatments required for sustained efficacy.